3 Tesla three-dimensional Fluid Attenuated Inversion

Recovery MR imaging in multiple sclerosisy

I. APRILE, M. NOBILI, A. KOULERIDOU, N. CAPUTO

Department of Neuroradiology, “S. Maria” Hospital, Terni, Italy

Summary

Progress in Neuroscience 2020; 5 (3-4): 37-45.

AIMS. Magnetic resonance brain evaluation in multiple sclerosis must be made by sequences that
enable you to display the largest possible number of lesions. In our study, carried out with a 3 Tesla equipment, we compared a new three-dimensional fluid attenuated inversion recovery sequence with the conventional ones in order to establish whether it can be used, instead of the other, for the multiple sclerosis patients evaluation.
MATERIALS AND METHODS. The sequences used were proton density, fast spin echo T2-weighted, two- and threedimensional fluid attenuated inversion recovery. Preliminarily, we acquired these sequences in 5 healthy volunteers and subsequently in 40 patients with clinically definite multiple sclerosis. The impact of any artefacts in all 4 sequences was evaluated. Afterwards the contrast resolution between lesions and the surrounding tissue was compared among all the sequences. Finally the number of lesions visualized with the 4 sequences was evaluated: both the total number of plaques and partial subgroups, according to lesions location and size.
RESULTS. In some cases (6/40) artefacts in three-dimensional fluid attenuated inversion recovery sequences were present both in volunteers and in patients. The contrast resolution was similar between fast spin echo T2-weighted, two- and three-dimensional fluid attenuated inversion recovery, whereas it was significantly lower in the PD images. Finally, as regards the number of lesions displayed, three-dimensional fluid attenuated inversion recovery sequences proved better than the other in all brain locations and especially as regards the small lesions assessment.
CONCLUSIONS. The three-dimensional fluid attenuated inversion recovery sequences, in 3 Tesla magnetic resonance studies, may be considered as the best choice for the multiple sclerosis patient study.

KEY WORDS: Fluid attenuated inversion recovery sequence, Magnetic resonance, Multiple sclerosis.

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