PiN - Vol. 5 N. 1-4 - 2020


		Summary

		Progress in Neuroscience 5 (1-4): 59-60.

		Opsoclonus-myoclonus syndrome is a rare immune-mediated disease in adults. However the pathogenic role is not well understood. We assessed wether there was an association between Opsoclonusmyoclonus syndrome and the positivity for Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) infection. A 58 years old man with symptomatology suggestive of opsoclonus-myoclonus syndrome was admitted to our hospital; during the hospitalization he developed a typical radiological pattern for COVID-19 pneumoniae. He was studied for possible immuno-mediated causes of the disease or correlation to SARS-CoV-2 infectio. MR imaging, electroencephalography and cerebrospinal fluid examination was normal as the detection of antibodies to neuronal surface antigens. A total body CT scan revealed a typical pattern of ground glass opacities in both lungs. Naso-pharyngeal swab was repeated and revealed a positivity for SARS-CoV-2. Reverse transcriptase-polymerase chain reaction for Sars-CoV-2 RNA in the cerebrospinal fluid was negative. Patient was transferred to a COVID-19 Department. In the following days, a progressive improvement was observed. Number of patients with COVID-19 experiencing different neurological signs and symptoms is rapidly growing in the literature. Opsoclonus-myoclonus syndrome should be added to the spectrum of clinical manifestations associated with this new disorder.
		KEY WORDS: COVID-19, Myoclonus Syndrome, Opsoclonus.

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